Bringing the e-nose to point-of-care

The ultimate goal of the e-nose is to be able to recognise diseases faster and in an earlier stage. To reach this goal, researchers of AMC have developed a new e-nose for utilisation in clinical care: the SpiroNose. AMC is currently testing the SpiroNose in the hectic day-to-day consulting hours in hospitals and general practices throughout the Netherlands.

Breath data of patients who underwent SpiroNose examination is stored in an extensive database, which is linked to a computer programme by a corresponding application (called BreathCloud). With this app, a patient’s breath will be analysed directly.

Rianne de Vries, Technical Physician: "Every patient we analyse will help making diagnoses more accurate. Our partners are therefore essential in this project; they help us by providing e-nose data for our vast database."

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E-nose research at the point-of-care

What consumes most time of physicians in daily medical care? Finding out what is wrong with a patient (diagnosis) and checking whether the patient gets better or worse over time (monitoring). Most symptoms and signs can be indicative of several diseases, which is why doctors usually perform blood tests or make X-rays to determine which disease causes the complaints.

Besides the fact that this process is time-consuming and often expensive, it is also aggravating for the patient, who has to come back several times for further laboratory assessments. In addition to this, these check-ups are sometimes even considered painful or stressful. We have got used to it, because these procedures cannot all be arranged in the doctor's office. Or can it be done?

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Webbing breathprints

for personalized medicine

Technological developments and research during the past decade has provided a sound scientific basis for the increasingly using of e-nose technology in clinical settings. Analysis of exhaled biomarkers by e-noses has however not yet been implemented in clinical practice due to the lack of clinically validated algorithms and databases that can be accessed where they are needed most: in the clinic. BreathCloud overcomes this problem by linking breath analysis equipment at the point-of-care with a continuously expanding online reference database of exhaled biomarker profiles (breathprints) and clinical patient characteristics

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Breath analysis

in 3 steps
Take a deep breath
and exhale through the SpiroNose
Data analysis by
Final report within
1 minute