Widespread usage of SpiroNose at point-of-care

The SpiroNose is an electronic nose (eNose) for medical application at point-of-care. It performs rapid and efficient analysis of exhaled air, allowing assessment of the most probable diagnosis in individual patients. Breath data of patients who underwent SpiroNose examination is stored in an extensive, online database, which is linked to an artificial intelligence (machine learning) application (called BreathCloud). This platform provides a real time answer at point-of-care within a few minutes. In addition, it allows collaboration between physicians and researchers using the database for shared analysis.

The system has been developed by the Academic Medical Centre (AMC) of the University of Amsterdam. Currently, it is predominantly used in lung diseases, such as asthma, COPD, lung cancer and respiratory infections. However, other applications are certainly possible. SpiroNose and BreathCloud are not only fast in examining the most probable diagnosis, it can also be used for subtyping (phenotyping) individual patients and for predicting the response to (novel) interventions (tailored therapy). Hereby the system meets the growing demand for precision- or personalized medicine.

Rianne de Vries, Technical Physician: "Every patient we analyse will help making diagnoses more accurate. Our partners are therefore essential in this project; they help us by providing eNose data for our vast database."

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E-nose research at the point-of-care

What consumes most time of physicians in daily medical care? Finding out what is wrong with a patient (diagnosis) and checking whether the patient gets better or worse over time (monitoring). Most symptoms and signs can be indicative of several diseases, which is why doctors usually perform blood tests or make X-rays to determine which disease causes the complaints.

Besides the fact that this process is time-consuming and often expensive, it is also aggravating for the patient, who has to come back several times for further laboratory assessments. In addition to this, these check-ups are sometimes even considered painful or stressful. We have got used to it, because these procedures cannot all be arranged in the doctor's office. Or can it be done?

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Webbing breathprints

for personalized medicine

Technological developments and research during the past decade has provided a sound scientific basis for the increasingly using of eNose technology in clinical settings. Analysis of exhaled biomarkers by eNoses has however not yet been implemented in clinical practice due to the lack of clinically validated algorithms and databases that can be accessed where they are needed most: in the clinic. BreathCloud overcomes this problem by linking breath analysis equipment at the point-of-care with a continuously expanding online reference database of exhaled biomarker profiles (breathprints) and clinical patient characteristics

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Breath analysis

in 3 steps
Take a deep breath
and exhale through the SpiroNose
Data analysis by
Final report within
1 minute